Kiel Marine Science

Research questions

The main interest is the elucidation of structure-function relationships of membrane proteins, in particular of channels and transporters. For this purpose, techniques for the production of the proteins (yeast cell-based and cell-free), for biochemical and biophysical functional analysis, and for the modulation of the function by mutation, secondary modification and small, drug-like molecules are applied.

Current questions:

  • What is the molecular mechanism of transport proteins for weak acids like lactate?
  • What is the pH dependence of the transport of weak acids based on?
  • Which path do co-transported protons take through the proteins?
  • Are channels and transporters of human pathogenic parasites such as the malaria pathogen suitable as new therapeutic targets?

 

Current Research

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